Original paper
Aβ oligomers trigger and accelerate Aβ seeding
Abstract
Aggregation of amyloid-β (Aβ) that leads to the formation of plaques in Alzheimer's disease (AD) occurs through the stepwise formation of oligomers and fibrils. An earlier onset of aggregation is obtained upon intracerebral injection of Aβ-containing brain homogenate into human APP transgenic mice that follows a prion-like seeding mechanism. Immunoprecipitation of these brain extracts with anti-Aβ oligomer antibodies or passive immunization of...
Paper Details
Title
Aβ oligomers trigger and accelerate Aβ seeding
Published Date
May 17, 2019
Journal
Volume
30
Issue
1
Pages
36 - 45