Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Volume: 30, Issue: 2, Pages: 352 - 363.e8
Published: Aug 1, 2019
Abstract
How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translation factor eukaryotic initiation factor 5A (eIF5A). We show here that hypusinated eIF5A (eIF5AH) promotes the efficient expression of a subset of mitochondrial proteins involved in the TCA cycle and oxidative phosphorylation (OXPHOS). Several of these proteins have...
Paper Details
Title
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
Published Date
Aug 1, 2019
Volume
30
Issue
2
Pages
352 - 363.e8
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