Histidine‐rich glycoprotein augments natural killer cell function by modulating PD ‐1 expression via CLEC ‐1B
Abstract
Augmentation of natural killer (NK) cell cytotoxicity is one of the greatest challenges for cancer immunotherapy. Although histidine-rich glycoprotein (HRG), a 75-kDa glycoprotein with various immunomodulatory activities, reportedly elicits antitumor immunity, its effect on NK cell cytotoxicity is unclear. We assessed NK cell cytotoxicity against K562 cells. We also measured concentrations of cytokines and granzyme B in the cell supernatant. The...
Paper Details
Title
Histidine‐rich glycoprotein augments natural killer cell function by modulating PD ‐1 expression via CLEC ‐1B
Published Date
May 22, 2019
Volume
7
Issue
3
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