Yoshito Nishimura
Okayama University
ProcalcitoninInternal medicineRadiologyMental healthDistressCross-sectional studyPathologyBurnoutCellCytotoxic T cellOdds ratioPsychologyDermatologyRetrospective cohort studyPolitical scienceChemistryImmunohistochemistryPathologicalBiopsyVasculitisHistidine-rich glycoproteinInflammationDepression (differential diagnoses)LymphomaIgG4-related diseaseDifferential diagnosisLesionCoronavirus disease 2019 (COVID-19)In patientCancer researchFamily medicineMedicinePandemicGastroenterology
Publications 33
#1Ryosuke Takase (Okayama University)
#2Hideharu Hagiya (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 8 authors...
A 75-year-old man with well-controlled type 2 diabetes was referred to our department because of urinary obstruction. He developed retroperitoneal fibrosis 1 year prior to the referral and underwent a ureteral stent insertion at that time. Around the same period, double vision and eyelid ptosis of the right eye coincidentally appeared (figure 1A). We performed MRI of the orbit; it revealed bilateral lacrimal enlargement, especially at the right side (figure 1B, C …
#1Atsuko Nasu (RMIT: RMIT University)H-Index: 2
#1Atsuko Nasu (RMIT: RMIT University)
Last. Yasuharu Sato (RMIT: RMIT University)H-Index: 32
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Differentiation between adult T-cell leukemia/lymphoma (ATLL) and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is often challenging based on pathological findings alone. Although serum anti-HTLV-1 antibody positivity is required for ATLL diagnosis, this information is often not available at the time of pathological diagnosis. Therefore, we examined whether the expression of SOX4 and p16 would be helpful for differentiating the two disease entities. We immunohistochemically exa...
Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by tissue fibrosis and intense lymphoplasmacytic infiltration, causing progressive organ dysfunction. Activation-induced cytidine deaminase (AID), a deaminase normally expressed in activated B-cells in germinal centers, edits ribonucleotides to induce somatic hypermutation and class switching of immunoglobulin. While AID expression is strictly controlled under physiological conditions, chronic inflammation has been ...
#1Yoshito Nishimura (U.H.: University of Hawaii at Manoa)H-Index: 5
#1Yoshito Nishimura (U.H.: University of Hawaii at Manoa)
Last. Fumio OtsukaH-Index: 35
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The coronavirus disease 2019 (COVID-19) global pandemic has drastically changed how we live and work. Amid the prolonged pandemic, burnout of the frontline healthcare professionals has become a significant concern. We conducted a cross-sectional survey study to provide data about the relationship between the COVID-19 pandemic and the prevalence of burnout in healthcare professionals in Japan. Healthcare workers in a single Japanese national university hospital participated in the survey, includi...
1 CitationsSource
#1Kazuya Nagasaki (University of Tsukuba)H-Index: 1
#2Kiyoshi Shikino (Chiba University)H-Index: 9
Last. Tetsuya Makiishi (Shimane University)H-Index: 2
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Objective The Mini-Z 2.0 is a new, simple, and nonproprietary tool for assessing physician well-being and burnout. To date, a non-English version of the Mini-Z 2.0 survey has not been validated. Therefore, we aimed to develop a Japanese version of the Mini-Z 2.0 and to evaluate its validity and reliability using survey data from physicians affiliated with an internal medicine academic society. Methods The Mini-Z 2.0 survey was translated into Japanese using a forward-backward translation method....
#1Yoshito Nishimura (Okayama University)H-Index: 5
#2Kanako Ochi (Okayama University)H-Index: 1
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 7 authors...
BACKGROUND: The COVID-19 pandemic has negatively affected medical education. However, little data are available about medical students' distress during the pandemic. OBJECTIVE: This study aimed to provide details on how medical students had been affected by the pandemic. METHODS: Cross-sectional study. 717 medical students participated in the web-based survey. The questions included how their mental status had changed before and after the Japanese nationwide state of emergency (SOE). RESULTS: 65...
1 CitationsSource
#1Tomoka Ikeda (Okayama University)H-Index: 2
#2Yuka Gion (RMIT: RMIT University)H-Index: 13
Last. Yasuharu Sato (Okayama University)H-Index: 32
view all 6 authors...
Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) was first described as a lymphoproliferative disorder in 2010. EBVMCU is a unifocal mucosal or cutaneous ulcer that often occurs after local trauma in patients with immunosuppression; the patients generally have a good prognosis. It is histologically characterized by proliferating EBV-positive atypical B cells accompanied by ulcers. On the basis of conventional pathologic criteria, EBVMCU may be misdiagnosed as EBV-positive diffuse l...
#1Yukinori Yoshii (Okayama University)H-Index: 3
#2Hidenori Wake (Okayama University)H-Index: 17
Last. Masahiro Nishibori (Okayama University)H-Index: 51
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Background: Histidine-rich glycoprotein (HRG) treatment ameliorated the survival rate of septic mice by suppressing excess immunothrombus formation. Although such findings suggested that HRG may be one of the most useful drugs for sepsis, obtaining a stable experimental system to standardize the HRG drug product is difficult to achieve using neutrophils isolated from volunteers. This is due to the short survival time and individual differences of human neutrophils. In the present study, we deter...
1 CitationsSource
Plasma cell type idiopathic multicentric Castleman disease (PC-iMCD) occasionally manifests as parenchymal lung disease. This study aimed to elucidate the detailed clinicopathological features of lung lesions in PC-iMCD and compare the findings with those in immunoglobulin (Ig) G4-related disease (IgG4-RD), the most difficult differential diagnosis of PC-iMCD. We analyzed the clinicopathological findings and immunohistochemical expression patterns of interleukin-6 (IL-6) and Igs in lung specimen...
#1Yuya Yokota (Okayama University)
#2Yoshito Nishimura (Okayama University)H-Index: 5
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 10 authors...
Alkaline phosphatase (ALP) is an enzyme that is expressed in a variety of tissues. Among the isoforms of ALP, bone-specific alkaline phosphatase (BAP) is used as a marker for evaluating bone metabolism. We investigated the clinical usefulness of the ratio of serum BAP to total ALP for the diagnosis of various disorders in general practice. We retrospectively analyzed the cases of 107 Japanese patients whose serum BAP levels were exam-ined, focusing on clinical characteristics. We observed that t...