Telomerase Triggered DNA Walker with a Superhairpin Structure for Human Telomerase Activity Sensing

Different from conventional DNA walkers, we designed a telomerase-triggered three-dimensional DNA walker consisting of a superhairpin structure with a bulged loop in the stem as the walking strand and dye-labeled tracks for ultrasensitive detection of telomerase activity. In the presence of telomerase, the primers in the stem of the superhairpin structure were elongated and triggered internal strand displacement, thus activating the superhairpin...