Characterization of psoriasiform dermatitis induced by systemic injection of interleukin‐23 minicircles in mice

The interleukin ( IL )‐23/ IL ‐17 axis plays a central role in the pathogenesis of psoriasis and is elevated in lesional psoriatic skin. Different murine models have been developed to mimic this pathophysiology each carrying specific merits and limitations. In an attempt to address some of these limitations, B10. RIII mice received a single hydrodynamic injection of IL ‐23 minicircles ( MC ) to induce hepatic transcription and the endogenous...