Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation
Abstract
Poly-ADP-ribose polymerases (PARPs) are a family of enzymes responsible for transferring individual or chains of ADP-ribose subunits to substrate targets as a type of post-translational modification. PARPs regulate a wide variety of important cellular processes, ranging from DNA damage repair to antiviral response. However, most research to date has focused primarily on the polyPARPs, which catalyze the formation of ADP-ribose polymer chains,...
Paper Details
Title
Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation
Published Date
Sep 1, 2019
Journal
Volume
167
Pages
97 - 106
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Notes
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