Biochemical Pharmacology
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#1Indira Purushothaman (PSU: Pennsylvania State University)H-Index: 3
#2Ian S. Zagon (PSU: Pennsylvania State University)H-Index: 71
Last. Patricia J. McLaughlin (PSU: Pennsylvania State University)H-Index: 66
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Abstract null null Diabetes is a multi-faceted disorder with increasing prevalence and rising healthcare costs. The burden of diabetes is increased because of associated complications affecting nearly all organs including the eye. The underlying pathophysiology for the onset of these ocular surface disorders is not well known. Enkephalins are endogenous opioids that originate in the brain and have numerous actions in the human body. Opioid growth factor (OGF), chemically termed [Met5]-enkephalin...
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#1Karol Kłopotowski (Wrocław Medical University)
#2Marta M. Czyzewska (Wrocław Medical University)H-Index: 7
Last. Jerzy W. Mozrzymas (Wrocław Medical University)H-Index: 26
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Abstract null null GABAA receptors (GABAARs) play a crucial role in mediating inhibition in adult mammalian brains. In the recent years, an impressive progress in revealing the static structure of GABAARs was achieved but the molecular mechanisms underlying their conformational transitions remain elusive. Phenylalanine 64 (α1F64) is located at the loop D of the orthosteric binding site of GABAAR and was found to directly interact with GABA molecule. Mutations of α1F64 were demonstrated to affect...
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#1Huiling Hong (CUHK: The Chinese University of Hong Kong)
#2Yiu Ming Cheung (CUHK: The Chinese University of Hong Kong)
Last. Xiao Yu Tian (CUHK: The Chinese University of Hong Kong)H-Index: 36
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Abstract null null The circadian clock plays an important role in adapting organisms to the daily light/dark cycling environment. Recent research findings reveal the involvement of the circadian clock not only in physiological functions but also in regulating inflammatory responses under pathological situations. Previous studies showed that the time-of-day variance of leucocyte circulation and pro-inflammatory cytokines secretion could be directly regulated by the clock-related proteins, includi...
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#1Enio Setsuo Arakaki Pacini (UNIFESP: Federal University of São Paulo)H-Index: 2
#2Edwin K. Jackson (University of Pittsburgh)H-Index: 84
Last. Rosely Oliveira Godinho (UNIFESP: Federal University of São Paulo)H-Index: 17
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Abstract null null In the respiratory tract, intracellular 3’,5’-cAMP mediates smooth muscle relaxation triggered by the β2-adrenoceptor/ Gs protein/ adenylyl cyclase axis. More recently, we have shown that β2-adrenoceptor agonists also increase extracellular 3’,5’-cAMP levels in isolated rat trachea, which leads to contraction of airway smooth muscle. In many other tissues, extracellular 3’,5’-cAMP is metabolized by ectoenzymes to extracellular adenosine, a catabolic pathway that has never been...
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Abstract The circadian wake drive is a mathematic representation of the observed increased propensity to stay awake late in the day, peaking in the hours just before anticipated bed time. It has been called the “forbidden zone” due to the difficulty in initiating sleep during this time and is responsible for the problems initiating sleep when traveling eastward, for maintaining daytime sleep in shift workers, and for initiating sleep in some individuals with insomnia. Evidence culled from studie...
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#1Marcos G. Frank (Washington State University Spokane)H-Index: 32
Abstract Sleep has been hypothesized to renormalize synapses potentiated in wakefulness. This is proposed to lead to a net reduction in synaptic strength after sleep in brain areas like the cortex and hippocampus. Biological clocks, however, exert independent effects on these synapses that may explain some of the reported differences after wake and sleep. These include changes in synaptic morphology, molecules and efficacy. In this commentary, I discuss why no firm conclusions should be drawn co...
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#1Whitney Stee (ULB: Université libre de Bruxelles)H-Index: 1
#2Philippe Peigneux (ULB: Université libre de Bruxelles)H-Index: 57
Abstract Neuroplasticity refers to the fact that our brain can partially modify both structure and function to adequately respond to novel environmental stimulations. Neuroplasticity mechanisms are not only operating during the acquisition of novel information (i.e., online) but also during the offline periods that take place after the end of the actual learning episode. Structural brain changes as a consequence of learning have been consistently demonstrated on the long term using non-invasive ...
1 CitationsSource
#1Carolin Reichert (University of Basel)H-Index: 12
#2Simon Veitz (University of Basel)H-Index: 1
Last. Janine Weibel (University of Basel)H-Index: 3
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Abstract Adolescents often suffer from short and mistimed sleep. To counteract the resulting daytime sleepiness they frequently consume caffeine. However, caffeine intake may exaggerate sleep problems by disturbing sleep and circadian timing. In a 28-hour double-blind randomized crossover study, we investigated to what extent caffeine disturbs slow-wave sleep (SWS) and delays circadian timing in teenagers. Following a 6-day ambulatory phase of caffeine abstinence and fixed sleep-wake cycles, 18 ...
1 CitationsSource
#1Apiwan Arinno (CMU: Chiang Mai University)H-Index: 4
#2Chayodom Maneechote (CMU: Chiang Mai University)H-Index: 6
Last. Siriporn C. Chattipakorn (CMU: Chiang Mai University)H-Index: 42
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Abstract null null Doxorubicin (Dox) is widely used in chemotherapy regimens for several malignant conditions. Unfortunately, cumulative and irreversible cardiotoxicity of Dox is the most prominent adverse effect which limits its use. Several pharmacological interventions which exert antioxidant properties, including melatonin and metformin, have demonstrated beneficial effects against various cardiac pathological conditions. However, the exact molecular mechanisms underlying their cardioprotect...
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#1Juliana M. Parente (USP: University of São Paulo)H-Index: 4
#2Marcela M. Blascke de Mello (USP: University of São Paulo)H-Index: 2
Last. Richard Schulz (U of A: University of Alberta)H-Index: 68
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Abstract null null Purpose null Cardiac transition from concentric (C-LVH) to eccentric left ventricle hypertrophy (E-LVH) is a maladaptive response of hypertension. Matrix metalloproteinases (MMPs), in particular MMP-2, may contribute to tissue remodeling by proteolyzing extra- and intracellular proteins. Troponin I and dystrophin are two potential targets of MMP-2 examined in this study and their proteolysis would impair cardiac contractile function. We hypothesized that MMP-2 contributes to t...
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