Ursodeoxycholic acid accelerates bile acid enterohepatic circulation

Background and Purpose Ursodeoxycholic acid (UDCA) is the first‐line treatment for primary biliary cholangitis, but its effects on the enterohepatic circulation of bile acid (BA) have been under‐investigated. Therefore, we studied the influence of UDCA on BA enterohepatic circulation in vivo and the mechanisms by which UDCA affects the BA kinetics. Experimental Approach Mice were treated with UDCA and other BAs to observe changes in BA pool and...