Keloid treatment: what about adjuvant radiotherapy?

Published on May 3, 2019in Clinical, Cosmetic and Investigational Dermatology1.97
· DOI :10.2147/CCID.S202884
Ilias G Petrou1
Estimated H-index: 1
(University of Geneva),
Kheeldass Jugun2
Estimated H-index: 2
+ 3 AuthorsBrigitte Pittet-Cuénod13
Estimated H-index: 13
(University of Geneva)
Keloids are debilitating fibrous skin proliferations with a high recurrence rate after surgical treatment. Postoperative radiotherapy (PORT) is a well-tolerated adjuvant treatment to reduce the risk of recurrence, but the optimal regimen for this combined treatment remains unknown. The aim of this study is to evaluate the efficacy of combining surgical excision and immediate PORT.
#1Nikoo N Cheraghi (UMN: University of Minnesota)H-Index: 2
#2Armand Cognetta (UMN: University of Minnesota)H-Index: 1
Last. David Goldberg (UMN: University of Minnesota)H-Index: 1
view all 3 authors...
: BACKGROUND: Radiotherapy has been used historically to treat a wide variety of dermatologie conditions, including nonmelanoma skin cancers, lymphomas, and inflammatory skin conditions. Recently, radiotherapy has been used increasingly as a valuable tool in the postsurgical treatment of large or recalcitrant keloids. OBJECTIVE: The objective of this review was to explore the use of radiation therapy as an adjuvant to surgically excised keloids. DESIGN: A PubMed search of all published English l...
14 Citations
Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. The latter is characterized by contin...
247 CitationsSource
#1J. EraudH-Index: 1
#2D. GonnelliH-Index: 2
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#1Xianglin Dong (First Affiliated Hospital of Xinjiang Medical University)H-Index: 1
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It was previously demonstrated that the main cause behind keloid formation may be keloid fibroblast abnormalities, which are closely associated with the microenvironment of the keloid lesion. The post-traumatic and chronic inflammation of the keloid lesion area suggest that inflammatory mediators play an important role in the keloid microenvironment and are crucial for keloid fibroblast abnormalities. In this study, we hypothesized that the mechanism underlying keloid formation may involve the c...
46 CitationsSource
#1Sara Ud-Din (University of Manchester)H-Index: 12
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Intralesional corticosteroid injection is a well-recognised treatment modality for keloid disease (KD). Approximately 50 % of KD cases are considered non-responders (or steroid resistant) with no consensus or indicators in detecting steroid-sensitive cases. In view of the undesirable side effects, uncertainty in timing and regularity of steroid treatment, we planned to identify responders and non-responders to target treatment more effectively. A scar injection proforma was developed capturing a...
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#1Fabianne Furtado (UNIFESP: Federal University of São Paulo)H-Index: 10
#2Bernardo Hochman (UNIFESP: Federal University of São Paulo)H-Index: 19
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#1Yaron Har-Shai (Rappaport Faculty of Medicine)H-Index: 23
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68 CitationsSource
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AbstractBackground: Keloid scars continue to be a complex and poorly understood subject. The main problem faced by researchers is the lack of an animal model because keloids affect only humans. Traditional techniques for keloids and hypertrophic scars are still availble. More recently, lasers have gained an increasing role in the treatment of hypertrophic scars and keloids. Methods: A total of 37 consecutive patients (31 females and six males; F:M=5:1 ratio) with 48 scars (34 hypertrophic and 14...
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