Keloid treatment: what about adjuvant radiotherapy?

Published on May 3, 2019in Clinical, Cosmetic and Investigational Dermatology1.97
· DOI :10.2147/CCID.S202884
Ilias G Petrou1
Estimated H-index: 1
(University of Geneva),
Kheeldass Jugun2
Estimated H-index: 2
+ 3 AuthorsBrigitte Pittet-Cuénod13
Estimated H-index: 13
(University of Geneva)
Sources
Abstract
Keloids are debilitating fibrous skin proliferations with a high recurrence rate after surgical treatment. Postoperative radiotherapy (PORT) is a well-tolerated adjuvant treatment to reduce the risk of recurrence, but the optimal regimen for this combined treatment remains unknown. The aim of this study is to evaluate the efficacy of combining surgical excision and immediate PORT.
References42
Newest
#1Nikoo N Cheraghi (UMN: University of Minnesota)H-Index: 2
#2Armand Cognetta (UMN: University of Minnesota)H-Index: 1
Last. David Goldberg (UMN: University of Minnesota)H-Index: 1
view all 3 authors...
: BACKGROUND: Radiotherapy has been used historically to treat a wide variety of dermatologie conditions, including nonmelanoma skin cancers, lymphomas, and inflammatory skin conditions. Recently, radiotherapy has been used increasingly as a valuable tool in the postsurgical treatment of large or recalcitrant keloids. OBJECTIVE: The objective of this review was to explore the use of radiation therapy as an adjuvant to surgically excised keloids. DESIGN: A PubMed search of all published English l...
14 Citations
Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. The latter is characterized by contin...
247 CitationsSource
#1J. EraudH-Index: 1
#2D. GonnelliH-Index: 2
Last. Guy MagalonH-Index: 20
view all 7 authors...
Resume Objectif Evaluer l’efficacite de la tomographie par coherence optique plein-champ pour differencier les cicatrices hypertrophiques des cicatrices cheloides sur des fragments tissulaires ex-vivo. Patients et methodes Tous les patients ayant beneficie de l’exerese d’une cicatrice pathologique entre novembre 2012 et septembre 2013 ont ete analyses. Les cicatrices ont ete fixees dans du formol puis analysees en histologie classique puis en tomographie a coherence optique plein-champ. Les crit...
3 CitationsSource
#1Xianglin Dong (First Affiliated Hospital of Xinjiang Medical University)H-Index: 1
#2Shaolin Mao (First Affiliated Hospital of Xinjiang Medical University)H-Index: 1
Last. Hao Wen (First Affiliated Hospital of Xinjiang Medical University)H-Index: 1
view all 3 authors...
It was previously demonstrated that the main cause behind keloid formation may be keloid fibroblast abnormalities, which are closely associated with the microenvironment of the keloid lesion. The post-traumatic and chronic inflammation of the keloid lesion area suggest that inflammatory mediators play an important role in the keloid microenvironment and are crucial for keloid fibroblast abnormalities. In this study, we hypothesized that the mechanism underlying keloid formation may involve the c...
46 CitationsSource
#1Sara Ud-Din (University of Manchester)H-Index: 12
#2Alison Bowring (University of Manchester)H-Index: 2
Last. Ardeshir Bayat (University of Manchester)H-Index: 62
view all 5 authors...
Intralesional corticosteroid injection is a well-recognised treatment modality for keloid disease (KD). Approximately 50 % of KD cases are considered non-responders (or steroid resistant) with no consensus or indicators in detecting steroid-sensitive cases. In view of the undesirable side effects, uncertainty in timing and regularity of steroid treatment, we planned to identify responders and non-responders to target treatment more effectively. A scar injection proforma was developed capturing a...
17 CitationsSource
#1Fabianne Furtado (UNIFESP: Federal University of São Paulo)H-Index: 10
#2Bernardo Hochman (UNIFESP: Federal University of São Paulo)H-Index: 19
Last. L.M. Ferreira (UNIFESP: Federal University of São Paulo)H-Index: 11
view all 3 authors...
Summary Introduction Evaluation tools are used to quantify scar evolution and determine treatment effectiveness. In clinical practice, scar assessment scales are less costly, tend to cover a greater number of aspects related to scar characteristics and can incorporate a patient's opinion in the assessment. However, the scales have not yet been used as an evaluation method for the postoperative recurrence of keloids. Objective The study aims to evaluate the effectiveness of scar rating scales for...
17 CitationsSource
#2Young-Jun Choi (SKKU: Sungkyunkwan University)H-Index: 7
#3Won-Serk Kim (SKKU: Sungkyunkwan University)H-Index: 16
Last. Ga-Young Lee (SKKU: Sungkyunkwan University)H-Index: 6
view all 4 authors...
BACKGROUND Prediction of whether postoperative wound healing will result in a hypertrophic scar or keloid is difficult. Diverse treatment options have been developed in an effort to prevent excessive scar formation. OBJECTIVE To evaluate the efficacy and safety of a 532-nm potassium titanyl phosphate (KTP) laser in the prevention of scar formation after total thyroidectomy. MATERIALS AND METHODS Twenty-eight individuals with Fitzpatrick skin types IV and V and linear surgical suture lines after ...
23 CitationsSource
#1Yaron Har-Shai (Rappaport Faculty of Medicine)H-Index: 23
#2I. Mettanes (Technion – Israel Institute of Technology)H-Index: 1
Last. M. PinesH-Index: 1
view all 6 authors...
Background Keloid presents a great healthcare challenge. The patients suffer from aesthetic disfiguration and occasionally from pruritus, pain and discomfort. Although various treatments are recommended, a single, highly effective treatment represents a great clinical need. Objective The cellular events and histopathology that follow intralesional cryosurgery were evaluated including cell proliferation, the number of cells expressing fibroblast markers, collagen synthesis and organization and ma...
27 CitationsSource
#1Tae Hwan Park (SKKU: Sungkyunkwan University)H-Index: 12
#2Sang Won SeoH-Index: 50
Last. Choong Hyun ChangH-Index: 10
view all 4 authors...
Background:In a previous study, the authors described an adjuvant pressure therapy using magnets for the management of ear keloids. The purpose of the present study was to build on this previous study by expanding the cohort of patients, evaluating treatment outcomes by means of a prospective study
68 CitationsSource
#1Daniel Cassuto (University of Catania)H-Index: 8
#2Luca Scrimali (University of Catania)H-Index: 3
Last. Paolo Siragò (University of Catania)H-Index: 3
view all 3 authors...
AbstractBackground: Keloid scars continue to be a complex and poorly understood subject. The main problem faced by researchers is the lack of an animal model because keloids affect only humans. Traditional techniques for keloids and hypertrophic scars are still availble. More recently, lasers have gained an increasing role in the treatment of hypertrophic scars and keloids. Methods: A total of 37 consecutive patients (31 females and six males; F:M=5:1 ratio) with 48 scars (34 hypertrophic and 14...
20 CitationsSource
Cited By8
Newest
BACKGROUND The portfolio of hyaluronic acid (HA) fillers and the techniques of administration have evolved in recent years. The latest innovation in the Vycross® range was the introduction of VYC-25L (Juvederm Volux® ; Allergan plc), a first-in-class filler effective for chin and facial lower third remodeling. The aim here was to provide clinicians who are starting to use VYC-25L with key advice, and to standardize procedures so that optimal and predictable outcomes can be obtained. METHODS A mu...
Source
#1Wenfang Dong (Peking Union Medical College)
#2Bin Qiu (PKU: Peking University)
Last. Fei Fan (Peking Union Medical College)H-Index: 4
view all 3 authors...
Radiotherapy is one of the therapeutic methods for keloids, and the irradiation technique has innovated from superficial X-ray to brachytherapy after decades of clinical practice. At present, the application of adjuvant radiotherapy has been widely accepted by clinicians, while the consensus of optimal adjuvant radiotherapy strategies for keloids has not been reached. Factors such as radiation timing, dose, fractions, and lesion locations may be associated with the clinical outcomes of patients ...
1 CitationsSource
#1Agnieszka Owczarczyk-Saczonek (University of Warmia and Mazury in Olsztyn)H-Index: 10
#2Natalia Zdanowska (University of Warmia and Mazury in Olsztyn)H-Index: 2
Last. Waldemar Placek (University of Warmia and Mazury in Olsztyn)H-Index: 12
view all 4 authors...
Hyaluronic acid (HA) is a glycosaminoglycan, a natural component of the extracellular matrix. The identical structure of the molecule in all living organisms is its main advantage, as it translates into the minimal probability of immunogenicity. Therefore, it is the closest to the ideal preparation used as a filler, due to its biocompatibility and stability at the site of implantation. This paper includes the discussion of the potential mechanisms of adverse immune reactions to HA along with the...
Source
#1Pengfei SunH-Index: 2
#2Zhensheng Hu (SDU: Shandong University)H-Index: 2
Last. Xiaosheng Lu (WMU: Weifang Medical University)H-Index: 2
view all 4 authors...
AbstractKeloid is a common and frequently-occurring disease in plastic surgery, and its ugly appearance and itching symptoms bring mental and life pain to patients. However, the clinical treatment ...
2 CitationsSource
#1Ofir Artzi (Tel Aviv Sourasky Medical Center)H-Index: 7
#2Sarit CohenH-Index: 18
Last. Or Friedman (Tel Aviv Sourasky Medical Center)H-Index: 7
view all 5 authors...
BACKGROUND: Acne is a common condition that affects up to 80% of all adolescents. Scarring may affect some 95% as a function of severity and delay before treatment. The pathogenesis includes enzymatic degradation of collagen fibers and subcutaneous fat. OBJECTIVE: This study aimed to treat atrophic acne scars using the Dual-Plane injection of Hyaluronic Acid. METHODS: A total of 12 patients with moderate-to-severe atrophic acne scars were treated with a novel NAHYCO™ based Hyaluronic Acid filler...
3 CitationsSource
#1Ziyad Abdullah AlHarbi (KSU: King Saud University)H-Index: 1
#2Hind M. Alkatan (KSU: King Saud University)H-Index: 13
Last. Adel H. Alsuhaibani (KSU: King Saud University)H-Index: 10
view all 3 authors...
Abstract Purpose To report the long-term follow-up results after surgical excision of migrated Bio-Alcamid fillers to the Periorbita area. Methods A retrospective case series of all patients who underwent surgical removal of migrated Bio-Alcamid fillers to the Periorbita area with minimal follow-up of 1 year from January 2009 to January 2018 was done. Results 16 female patients (24–52 y) presented with an upper or lower eyelid swelling 3–7 years following a filler injection in the nasal bridge, ...
2 CitationsSource
#1Ines Verner (Sapienza University of Rome)H-Index: 4
#2Hadas Prag NavehH-Index: 2
Last. Dario Bertossi (University of Verona)H-Index: 17
view all 3 authors...
: An increasing number of minimally invasive cosmetic procedures, such as filler or botulinum toxin injections, are performed annually. These procedures are associated with a high risk of post-procedure bruising or ecchymosis. Ecchymoses arise following hemorrhage and extravasation of red blood cells into the subcutaneous tissue, leading to local skin discoloration. Although ecchymoses generally resolve within 14 days, their appearance is cosmetically bothersome, and they may be painful and caus...
4 CitationsSource
#1Pasquale Fino (Sapienza University of Rome)H-Index: 10
#2Marco Toscani (Sapienza University of Rome)H-Index: 7
Last. Nicolò Scuderi (Sapienza University of Rome)H-Index: 31
view all 5 authors...
Introduction The current study compares two hyaluronic acid fillers, Ial System Duo and Belotero Basic/Balance, for the treatment of wrinkles.
6 CitationsSource