Impact of choice of feeding tubes on long-term swallow function following chemoradiotherapy for oropharyngeal carcinoma.

Published on Apr 29, 2019in Acta Oncologica3.701
· DOI :10.1080/0284186X.2019.1609698
Robin Prestwich28
Estimated H-index: 28
,
Louise Murray18
Estimated H-index: 18
+ 8 AuthorsS. Ramasamy6
Estimated H-index: 6
Sources
Abstract
AbstractBackground: Prior reports have raised concerns that a prophylactic gastrostomy may be detrimental to long-term swallow function. This study evaluates patient-reported swallow function follo...
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Abstract Background and purpose Limited data are available to inform on long term swallowing outcomes following concurrent chemoradiotherapy for oropharyngeal carcinoma. The aims of this study are to determine long term patient-reported swallowing outcomes across two large UK centres in routine clinical practice and identify associated factors. Material and methods All patients treated for oropharyngeal squamous cell carcinoma with concurrent chemoradiotherapy, and irradiation of the bilateral n...
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#1Vinidh Paleri (Newcastle University)H-Index: 42
#2Joanne Patterson (Newcastle University)H-Index: 19
Last. Deborah D. Stocken (Newcastle University)H-Index: 33
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Background - Approximately 9000 new cases of head and neck squamous cell cancers (HNSCCs) are treated by the NHS each year. Chemoradiation therapy (CRT) is a commonly used treatment for advanced HNSCC. Approximately 90% of patients undergoing CRT require nutritional support via gastrostomy or nasogastric tube feeding. Long-term dysphagia following CRT is a primary concern for patients. The effect of enteral feeding routes on swallowing function is not well understood, and the two feeding methods...
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#1Lars Axelsson (Sahlgrenska University Hospital)H-Index: 3
#2Ewa Silander (Sahlgrenska University Hospital)H-Index: 11
Last. Eva Hammerlid (Sahlgrenska University Hospital)H-Index: 34
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Background Dysphagia is common in head and neck cancer. A percutaneous endoscopic gastrostomy (PEG) tube is used to facilitate nutrition; however, some retrospective studies have indicated that the PEG tube causes dysphagia. Methods A randomized study of patients with head and neck cancer was conducted with up to 10 years of follow-up. Patients were randomized to either the prophylactic PEG tube group (study group) or the common clinical nutritional support group (control group). At each follow-...
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#1Vincent Grégoire (UCL: Université catholique de Louvain)H-Index: 70
#2Mererid EvansH-Index: 17
Last. Cai Grau (AU: Aarhus University)H-Index: 60
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Abstract Purpose Few studies have reported large inter-observer variations in target volume selection and delineation in patients treated with radiotherapy for head and neck squamous cell carcinoma. Consensus guidelines have been published for the neck nodes (see Gregoire et al., 2003, 2014), but such recommendations are lacking for primary tumour delineation. For the latter, two main schools of thoughts are prevailing, one based on geometric expansion of the Gross Tumour Volume (GTV) as promote...
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#1Diane GoffH-Index: 4
#2S. CowardH-Index: 1
Last. Joanne Patterson (Newcastle University)H-Index: 19
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Objectives There is currently no consensus on the optimal feeding route for an oropharyngeal squamous cell cancer (OPSCC) patient without pre-existing dysphagia undergoing chemoradiotherapy (CRT). This study aims to compare the swallowing outcomes for OPSCC patients fed via either prophylactic RIG (pRIG) or reactive naso-gastric tube (rNGT). Design A prospective cohort study. Setting Four head and neck cancer centres in the North of England Cancer Network. Participants Fifty-three participants w...
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#1Imran Petkar (The Royal Marsden NHS Foundation Trust)H-Index: 6
#2Keith Rooney (Belfast Health and Social Care Trust)H-Index: 6
Last. Christopher M. Nutting (The Royal Marsden NHS Foundation Trust)H-Index: 69
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Background Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients’ quality of life. Single arm studies have shown that the dosimetric sparing of critical swallowing structures such as the pharyngeal constrictor muscle and supraglottic larynx can translate to better functional outcomes. However, there are no current randomised studies to confirm the benefits of such swallow sparing strategies. The aim of Dysphagia/Aspiration...
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#2Mark TeoH-Index: 14
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Summary Objectives The purpose of this matched pair analysis is to assess patient-reported long term swallow function following chemoradiotherapy for locally advanced oropharyngeal cancer in relation to the use of a prophylactic gastrostomy or reactive nasogastric (NG) tube. Materials and methods The MD Anderson Dysphagia Inventory (MDADI) was posted to 68 consecutive patients with stage III/IV oropharyngeal squamous cell carcinoma who had completed parotid sparing intensity modulated radiothera...
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#1Katherine A. Hutcheson (University of Texas MD Anderson Cancer Center)H-Index: 33
#2Martha P. Barrow (University of Texas MD Anderson Cancer Center)H-Index: 11
Last. Jan S. LewinH-Index: 52
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Objective/Hypothesis To describe clinically relevant between-group differences in MD Anderson Dysphagia Inventory (MDADI) scores among head and neck cancer (HNC) patients. Study Design Retrospective cross-sectional study was conducted in 1,136 HNC patients seen for modified barium swallow (MBS) studies. Methods The MDADI was administered by written questionnaire at the MBS appointment. MD Anderson Dysphagia Inventory global, composite, and subscale scores were calculated. Anchor-based methods we...
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#1Jacqui Frowen (Peter MacCallum Cancer Centre)H-Index: 5
#2Allison Drosdowsky (Peter MacCallum Cancer Centre)H-Index: 5
Last. June Corry (University of Melbourne)H-Index: 47
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Background This prospective study evaluated long-term swallowing outcomes and associated risk factors 5 years postchemoradiotherapy for head and neck cancer. Methods Following an earlier study of 69 patients, 39 patients had patient-reported activity and quality of life (QOL) data collected. Twenty-one patients also underwent a videofluoroscopy swallowing study (VFSS). Results Between 6 months and 5 years posttreatment, patient-reported activity for solid foods significantly improved (p < .001),...
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#1Matthew C. WardH-Index: 15
#2Priyanka Bhateja (SHM: Society of Hospital Medicine)H-Index: 6
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Background Severe late dysphagia is common after chemoradiotherapy for cancers of the larynx and oropharynx. Options for reduction of severe late dysphagia are limited for human papillomavirus (HPV)-negative patients. In this study, the role of feeding tube choice in severe late dysphagia is investigated. Methods Patients disease-free after chemoradiotherapy for HPV-negative cancers of the laryngopharynx who received a feeding tube on-treatment were identified. The incidence of severe late dysph...
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#1Laura W. J. Baijens (UM: Maastricht University)H-Index: 22
#2Margaret Walshe (Trinity College, Dublin)H-Index: 18
Last. Pere Clavé (Autonomous University of Barcelona)H-Index: 50
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Purpose To develop a European White Paper document on oropharyngeal dysphagia (OD) in head and neck cancer (HNC). There are wide variations in the management of OD associated with HNC across Europe. Methods Experts in the management of specific aspects of OD in HNC across Europe were delegated by their professional medical and multidisciplinary societies to contribute to this document. Evidence is based on systematic reviews, consensus-based position statements, and expert opinion. Results Twent...
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