Carcinogenesis

Biology

Gene

Chemistry

Glioblastoma

Cell biology

Cancer research

Plasma protein binding

Fatty acid

Biochemistry

Beta oxidation

Cell Metabolism

Reprogramming of fatty acid metabolism in glioblastoma is a known phenomenon; however, the drivers of this process are little understood. Here, Duman et al. demonstrate that ACBP mediates the availability of fatty acyl-CoA into mitochondria, driving β-oxidation and promoting tumorigenesis. Removal of ACBP from tumors leads to widespread tumor senescence and increased survival of experimental animals.

Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation