Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin
Abstract
Tissue transglutaminase (TG2) is a multifunctional protein with enzymatic, GTP-ase, and scaffold properties. TG2 interacts with fibronectin (FN) through its N-terminus domain, stabilizing integrin complexes, which regulate cell adhesion to the matrix. Through this mechanism, TG2 participates in key steps involved in metastasis in ovarian and other cancers. High-throughput screening identified several small molecule inhibitors (SMI) for the...
Paper Details
Title
Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin
Published Date
Jun 1, 2019
Volume
18
Issue
6
Pages
1057 - 1068
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