<p>Long-lasting bactericidal activity through selective physical puncture and controlled ions release of polydopamine and silver nanoparticles–loaded TiO<sub>2 </sub>nanorods in vitro and in vivo</p>

Background: Titanium (Ti) implant-associated infection, which is mostly caused by bacterial adhesion and biofilm formation, may result in implant failure and secondary surgery. Thus it is an urgent issue to prevent bacterial infections at the earliest step. Purpose: To develop a novel surface strategy of polydopamine (PDA) and silver (Ag) nanoparticle-loaded TiO 2 nanorods (NRDs) coatings on Ti alloy. Materials and methods: Ag-TiO 2 @PDA NRDs...