Response to thrombopoietic agents is related to on‐treatment bone marrow megakaryocyte morphology in patients with chronic immune thrombocytopenia

Immune thrombocytopenia (ITP) is an autoimmune disease in which antiplatelet antibodies and T-cells mediate thrombocytopenia by a combination of accelerating platelet destruction and reducing platelet production. It is known that megakaryocytes are usually increased in number in chronic ITP (cITP), although a corollary increase in platelet count is not automatically seen.1 This suggests that the abundant megakaryocytes may be defective in...