Safety assessment of the pharmacological excipient, diethylene glycol monoethyl ether (DEGEE), using in vitro and in vivo systems

Published on Apr 18, 2019in Tehran University of Medical Sciences
· DOI :10.1007/S40199-019-00264-5
Sonal Srivastava7
Estimated H-index: 7
(Central Drug Research Institute),
Sakshi Mishra11
Estimated H-index: 11
(Central Drug Research Institute)
+ 7 AuthorsSrikanta Kumar Rath13
Estimated H-index: 13
(Central Drug Research Institute)
Sources
Abstract
Background Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Also, a few reports have raised concern on the use of DEGEE as it might cause damage to the kidneys.
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