Sakshi Mishra
Central Drug Research Institute
CytotoxicityRisk assessmentDNA damageChemistryApoptosisIn vivoOxidative stressCelecoxibBALB/cInflammationCytokinePopulationToxicityProgrammed cell deathComputer scienceReactive oxygen speciesCancer researchp38 mitogen-activated protein kinasesFood safetyGlutathioneBiochemistryMedicineMycotoxinPI3K/AKT/mTOR pathwayBiologyPharmacology
23Publications
11H-index
465Citations
Publications 19
Newest
#1Sonal SrivastavaH-Index: 7
#2Jayant DewanganH-Index: 9
Last. Srikanta Kumar RathH-Index: 13
view all 8 authors...
Abstract Background: Celecoxib (CXB), a selective COX-2 inhibitor NSAID, has exhibited prominent anti-proliferative potential against numerous cancers. However, its low bioavailability and long term exposure related cardiovascular side effects, limit its clinical application. In order to overcome these limitations, natural bioactive compounds with lower toxicity profile are used in combination with therapeutic drugs. Therfore, in this study Piperine (PIP), a natural chemo-preventive agent posses...
Source
#1Sakshi Mishra (Central Drug Research Institute)H-Index: 11
#2Aman Divakar (Central Drug Research Institute)H-Index: 4
Last. Srikanta Kumar Rath (Central Drug Research Institute)H-Index: 13
view all 10 authors...
Abstract Deoxynivalenol is a trichothecene mycotoxin which naturally contaminates small grain, cereals intended for human and animal consumption. Investigations for dermal toxicity of DON has been needed and highlighted by WHO. Previous studies on dermal toxicity suggest that DON has DNA damaging potential leading to skin tumor initiation in mice skin. However, little is known regarding its protection/prevention considering its toxicological manifestations arising after dermal exposure. Collecti...
2 CitationsSource
#1Sakshi Mishra (Central Drug Research Institute)H-Index: 3
#1Sakshi Mishra (Central Drug Research Institute)H-Index: 11
Last. Srikanta Kumar Rath (Central Drug Research Institute)H-Index: 13
view all 10 authors...
Abstract Exposure to mycotoxins is mostly by ingestion but also occurs by the dermal and inhalation routes. The present study for the first time demonstrated that mycotoxin Deoxynivalenol (DON), permeates through Swiss albino mice skin, which demands awareness of health risks in people who are dermally exposed to mycotoxins especially agricultural farmers. Despite the widespread contamination of DON in food commodities studies to alleviate DON's toxicity are sparsely reported. Thus effective mea...
3 CitationsSource
#1Sakshi Mishra (Central Drug Research Institute)H-Index: 11
#2Sonal Srivastava (Central Drug Research Institute)H-Index: 7
Last. Srikanta Kumar Rath (Central Drug Research Institute)H-Index: 13
view all 5 authors...
AbstractPreventing food from fungal infestation has become a cause of great concern as food safety is of particular importance to public health globally. Recently International Agency for Research ...
30 CitationsSource
#1Prachi Tewari (IITR: Indian Institute of Toxicology Research)H-Index: 3
#2Ruchi Roy (IITR: Indian Institute of Toxicology Research)H-Index: 12
Last. Mukul Das (IITR: Indian Institute of Toxicology Research)H-Index: 33
view all 10 authors...
Source
#1Jayant Dewangan (Central Drug Research Institute)H-Index: 9
#2Sonal Srivastava (Central Drug Research Institute)H-Index: 7
Last. Srikanta Kumar Rath (Central Drug Research Institute)H-Index: 13
view all 6 authors...
Abstract Cancer is a complex disease wherein cells begin to divide abnormally and spread into surrounding tissues. Angiogenesis plays a crucial role in tumor progression as it is required for sustained growth and metastasis, therefore targeting angiogenesis is a promising therapeutic approach for breast cancer management. Salinomycin (SAL) has been reported to exhibit anticancer response on various types of cancer. In the present study, we explored the antiangiogenic and anticancer efficacy of t...
11 CitationsSource
#1Sonal Srivastava (Central Drug Research Institute)H-Index: 7
#2Sakshi Mishra (Central Drug Research Institute)H-Index: 11
Last. Srikanta Kumar Rath (Central Drug Research Institute)H-Index: 13
view all 10 authors...
Background Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Also, a few reports have raised concern on the use of DEGEE as it might cause damage to the kidneys.
3 CitationsSource
#1Kinjal MunotH-Index: 1
#2Nishi MehtaH-Index: 1
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Organizations collect a huge amount of data and store it for compliance purpose. This data is not analyzed or processed and with time it gets dumped into the company’s database because there is no time or money with the organization to invest in this type of data. This paper discusses dark data, its importance, risks involved, the need and techniques to structure the unstructured part of dark data. It also discusses applications of dark data in the finance sector and what portions of the bank’s ...
Source
#1Jayant Dewangan (Central Drug Research Institute)H-Index: 9
#2Sonal Srivastava (Central Drug Research Institute)H-Index: 7
Last. Srikanta Kumar Rath (Central Drug Research Institute)H-Index: 13
view all 6 authors...
Abstract Human triple-negative breast cancer (TNBC) is poorly diagnosed and unresponsive to conventional hormone therapy. Chetomin (CHET), a fungal metabolite synthesized by Chaetomium cochliodes, has been reported as a promising anticancer and antiangiogenic agent but the complete molecular mechanism of its anticancer potential remains to be elucidated. In our study, we explored the anti-neoplastic action of CHET on TNBC cells. Cytotoxicity studies were performed in human TNBC cells viz. MDA-MB...
10 CitationsSource
#1Sonal Srivastava (Central Drug Research Institute)H-Index: 7
#2Sakshi Mishra (Central Drug Research Institute)H-Index: 11
Last. Srikanta Kumar Rath (Central Drug Research Institute)H-Index: 13
view all 6 authors...
Abstract In vitro assays for toxicological studies is the refinement and replacement of animal testing in order to minimize the use of traditional animal-based toxicology studies. In the recent decades, in vitro methods have been routinely used as these can be correlated with the in vivo studies and can help in understanding a specific in vivo response in any given species. Optimization of cell culture is the major primary step to in vitro studies as it includes handling of cells and tissues out...
2 CitationsSource