Original paper
IgG4‐related disease: Association with a rare gene variant expressed in cytotoxic T cells
Abstract
Family screening of a 48-year-old male with recently diagnosed IgG4-related disease (IgG4-RD) revealed unanticipated elevations in plasma IgG4 in his two healthy teenaged sons.We performed gene sequencing, immune cell studies, HLA typing, and analyses of circulating cytotoxic CD4+ T lymphocytes and plasmablasts to seek clues to pathogenesis. DNA from a separate cohort of 99 patients with known IgG4-RD was also sequenced for the presence of...
Paper Details
Title
IgG4‐related disease: Association with a rare gene variant expressed in cytotoxic T cells
Published Date
Apr 16, 2019
Volume
7
Issue
6
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Notes
History