Internal medicine

Neuroscience

Parahippocampal gyrus

Epilepsy

Disease

Insula

Psychiatry

Cognition

Physical therapy

Psychology

Anterior cingulate cortex

Neuropathology

Chronic pain

Temporal lobe

Medicine

British Journal of Anaesthesia

Previous studies have found widespread pain processing alterations in the brain in chronic low back pain (cLBP) patients. We aimed to (1) identify brain regions showing altered amplitude of low-frequency fluctuations (ALFF) using MRI and use these regions to discriminate cLBP patients from healthy controls (HCs) and (2) identify brain regions that are sensitive to cLBP pain intensity changes.

Identifying brain regions associated with the neuropathology of chronic low back pain: a resting-state amplitude of low-frequency fluctuation study