Original paper
IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival
Abstract
Lymph-node (LN) stromal cell populations expand during the inflammation that accompanies T cell activation. Interleukin-17 (IL-17)-producing helper T cells (TH17 cells) promote inflammation through the induction of cytokines and chemokines in peripheral tissues. We demonstrate a critical requirement for IL-17 in the proliferation of LN and splenic stromal cells, particularly fibroblastic reticular cells (FRCs), during experimental autoimmune...
Paper Details
Title
IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival
Published Date
Apr 8, 2019
Journal
Volume
20
Issue
5
Pages
534 - 545
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Notes
History