Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion

Uncontrolled bacteremia takes more human lives than any cancer. Neutrophil granulocytes are essential in containing and killing bacteria, and their repertoire includes producing Neutrophil Extracellular Traps (NETs), DNA-based net-like structures with antimicrobial activity. In sepsis, however, NETs are also known to worsen disseminated coagulation, promote venous thrombosis and are associated with worse outcomes in infections. Here, we describe...