Inside-Out Control of Fc-Receptors

Receptors recognizing the Fc-part of immunoglobulins (FcR) are important in the engagement of phagocytes with opsonized micro-organisms. Different FcRs are specifically recognizing and binding the different classes of immunoglobulins,transmitting different signals into the cell. The function of IgG (FcgammaR’s) and IgA (FcalphaR) recognizing receptors is controlled by cellular signals evoked by activation of heterologous receptors in a process...