Original paper
SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
Abstract
Heterozygous loss-of-function mutations in SHANK2 are associated with autism spectrum disorder (ASD). We generated cortical neurons from induced pluripotent stem cells derived from neurotypic and ASD-affected donors. We developed sparse coculture for connectivity assays where SHANK2 and control neurons were differentially labeled and sparsely seeded together on a lawn of unlabeled control neurons. We observed increases in dendrite length,...
Paper Details
Title
SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
Published Date
Mar 25, 2019
Journal
Volume
22
Issue
4
Pages
556 - 564
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Notes
History