Physics

Internal medicine

Fosfomycin

Antibiotics

Bacteria

Urinary system

Biology

Microbiology

Optics

Inelastic scattering

Urology

Surgery

Randomized controlled trial

Scattering

Piperacillin/tazobactam

ZEUS (particle detector)

Tazobactam

Pseudomonas aeruginosa

Piperacillin

Deep inelastic scattering

Genetics

Medicine

Clinical Infectious Diseases

ZTI-01 (fosfomycin for injection) is an epoxide antibiotic with a differentiated mechanism of action (MOA) inhibiting an early step in bacterial cell wall synthesis. ZTI-01 has broad in vitro spectrum of activity, including multidrug-resistant Gram-negative pathogens, and is being developed for treatment of complicated urinary tract infection (cUTI) and acute pyelonephritis (AP) in the United States.

Fosfomycin for Injection (ZTI-01) Versus Piperacillin-tazobactam for the Treatment of Complicated Urinary Tract Infection Including Acute Pyelonephritis: ZEUS, A Phase 2/3 Randomized Trial