Original paper
Methyl DNA phosphate adduct formation in lung tumor tissue and adjacent normal tissue of lung cancer patients
Abstract
The formation of methyl DNA adducts is a critical step in carcinogenesis initiated by the exposure to methylating carcinogens. Methyl DNA phosphate adducts, formed by methylation of the oxygen atoms of the DNA phosphate backbone, have been detected in animals treated with methylating carcinogens. However, detection of these adducts in human tissues has not been reported. We developed an ultrasensitive liquid chromatography-nanoelectrospray...
Paper Details
Title
Methyl DNA phosphate adduct formation in lung tumor tissue and adjacent normal tissue of lung cancer patients
Published Date
Mar 12, 2019
Journal
Volume
40
Issue
11
Pages
1387 - 1394
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Notes
History