Original paper
IL ‐35 ameliorates collagen‐induced arthritis by promoting TNF ‐α‐induced apoptosis of synovial fibroblasts and stimulating M2 macrophages polarization
Abstract
Synovitis, the chronic inflammation of the synovial membranes, is a hallmark of rheumatoid arthritis, a chronic disease with profound impact on human health. Recently, interleukin‐35 ( IL ‐35), a new member of the IL ‐12 family, was identified as an anti‐inflammatory and immunosuppressive cytokine and was shown to ameliorate collagen‐induced arthritis ( CIA ) in mice. However, the mechanism by which IL ‐35 alleviates CIA remains unknown. In this...
Paper Details
Title
Published Date
Mar 23, 2019
Journal
Volume
286
Issue
10
Pages
1972 - 1985
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Notes
History