Original paper
A Cell-Level Systems PK-PD Model to Characterize In Vivo Efficacy of ADCs
Abstract
Here, we have presented the development of a systems pharmacokinetics-pharmacodynamics (PK-PD) model for antibody-drug conjugates (ADCs), which uses intracellular target occupancy to drive in-vivo efficacy. The model is built based on PK and efficacy data generated using Trastuzumab-Valine-Citrulline-Monomethyl Auristatin E (T-vc-MMAE) ADC in N87 (high-HER2) and GFP-MCF7 (low-HER2) tumor bearing mice. It was observed that plasma PK of all ADC...
Paper Details
Title
A Cell-Level Systems PK-PD Model to Characterize In Vivo Efficacy of ADCs
Published Date
Feb 25, 2019
Journal
Volume
11
Issue
2
Pages
98 - 98
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Notes
History