ELMO1 deficiency enhances platelet function
Abstract
Phosphatidylinositol 3-kinase is an important signaling molecule that, once activated, leads to the generation of phosphatidylinositol (3,4,5)-trisphosphate (PIP3). We performed a proteomic screen to identify PIP3-interacting proteins in human platelets. Among these proteins, we found engulfment and cell motility 1 (ELMO1), a scaffold protein with no catalytic activity. ELMO1 is expressed in platelets and interacts with active RhoG. However, the...
Paper Details
Title
ELMO1 deficiency enhances platelet function
Published Date
Feb 20, 2019
Journal
Volume
3
Issue
4
Pages
575 - 587
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