Inflammatory Activity of Tumoral Calcinosis in a Patient With Fever of Unknown Origin.

Published on Apr 1, 2019in Clinical Nuclear Medicine6.587
· DOI :10.1097/RLU.0000000000002497
Falk Gühne4
Estimated H-index: 4
,
Robert Drescher5
Estimated H-index: 5
+ 2 AuthorsMartin Freesmeyer14
Estimated H-index: 14
Sources
Abstract
AbstractUnexpected inflammatory activity of tumoral calcinosis periarticular to the shoulders and hips in a man with recurrent fever of unknown origin and dialysis-dependent kidney insufficiency was revealed by FDG PET/CT. In absence of other pathologies, the calcinosis was deemed to be the cause of
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References9
Newest
#1Jesper StrandbergH-Index: 2
#2Helle D ZachoH-Index: 14
Tumoral calcinosis is a benign condition characterized by periarticular calcified lesions that is frequently observed in patients with chronic renal failure. Tumoral calcinosis often presents with subcutaneous masses and joint swelling. We present a case of tumoral calcinosis with dramatically increased 18F-fluoro-2-deoxy-d-glucose (18F-FDG) uptake on positron emission tomography/computed tomography (PET/CT) that mimicked lymphoma or lymph node metastases.
2 CitationsSource
#1Rui Guo (Mie University)H-Index: 1
#2Tatsuya KurataH-Index: 1
Last. Yuichi Kasai (Mie University)H-Index: 18
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Background Tumoral calcinosis is rarely located in spine. A 55-year-old Japanese woman with cervical tumoral calcinosis is presented, along with a review of the literature relating to tumoral calcinosis in the spine. We discussed the etiology, diagnosis, and management of this condition.
7 CitationsSource
#1Yiyan Liu (RU: Rutgers University)H-Index: 19
Tumoral calcinosis is a rare family disorder characterized by massive periarticular calcification deposits of the soft tissue. Although radiographic findings of tumoral calcinosis are recognized, there were very scant publications of scintigraphic imaging of the disease. We present here the images of FDG PET/CT and bone scintigraphy in a patient with idiopathic tumoral calcinosis, which are unique in the locations of the lesions and distribution of abnormal uptake.
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#1Sriram VaidyanathanH-Index: 15
#2Chirag PatelH-Index: 13
Last. Fahmid U. ChowdhuryH-Index: 18
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Integrated positron emission tomography/computed tomography (PET/CT) with the glucose analogue, 2-[ 18 F]-fluoro-2-deoxy- d -glucose (FDG), is an evolving hybrid imaging technique in the evaluation of an important and diverse group of pathological conditions, which are characterised by infection and aseptic inflammation. With a rapidly expanding body of evidence, it is being increasingly recognised that, in addition to its established role in oncological imaging, FDG PET/CT also has clinical uti...
169 CitationsSource
#1François Jamar (UCL: Université catholique de Louvain)H-Index: 26
#1François Jamar (UCL: Université catholique de Louvain)H-Index: 22
Last. Alberto SignoreH-Index: 57
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1Department of Nuclear Medicine, Universite Catholique de Louvain, Brussels, Belgium; 2Department of Nuclear Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom; 3Nuclear Medicine, Istituto Clinico Humanitas, Milan, Italy; 4Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; 5Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee; 6Department of Nuclear Medicine, Beth Israel Deaconess Medical Center, Boston, Mas...
318 CitationsSource
#1Torsten MummeH-Index: 13
#2H. GriefingholtH-Index: 2
Last. A. KochsH-Index: 2
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: The tumoral calcinosis (synonym: Teutschlander disease) is a very rare benign metabolic dysfunction of unknown etiology. It manifests principally as massive subcutaneous soft tissue deposits of calcium phosphate near the large joints and is also characterized by slow progressive growth. Causally, a disturbance of the calcium and phosphate metabolism/balance with, among others, autosomal dominant heredity is suspected. It appears frequently in the black African population in all age groups, but...
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#1Steven Vanderschueren (Katholieke Universiteit Leuven)H-Index: 33
#2Daniel KnockaertH-Index: 29
Last. Herman BobbaersH-Index: 22
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Background Epidemiological changes and the ongoing expansion of the diagnostic armamentarium warrant a regular update of the spectrum of diseases that present as prolonged febrile illnesses. Methods We prospectively collected a series of 290 immunocompetent patients referred to our university hospital between 1990 and 1999 with a febrile illness (temperature >38.3°C) of uncertain cause, lasting at least 3 weeks. Patients were categorized in 4 groups according to the timing of diagnosis: early di...
203 CitationsSource
#1Serdar Tezelman (UCSF: University of California, San Francisco)H-Index: 23
#2Allan Siperstein (UCSF: University of California, San Francisco)H-Index: 79
Last. Orlo H. Clark (UCSF: University of California, San Francisco)H-Index: 99
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Objective: To examine our experience and review the literature concerning the diagnosis, origin, and treatment of tumoral calcinosis (TC). Design/Setting: Case series based on patients with TC treated in University of California—San Francisco hospitals from 1981 to 1992 and the review of the patients described in the English-language literature. Patients: The study included a total of 17 patients: 10 women and seven men. Main Outcome Measures: Sex, age, origin, symptoms, localization, treatment,...
63 CitationsSource
#1Steven F. Viegas (UTMB: University of Texas Medical Branch)H-Index: 48
#2E. Burke Evans (UTMB: University of Texas Medical Branch)H-Index: 13
Last. Steven E. Goodwiller (UTMB: University of Texas Medical Branch)H-Index: 1
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Tumoral calcinosis rarely occurs in the hand. It is an uncommon familial disease suggesting an autosomal recessive gene pattern, often with laboratory findings of hyperphosphatemia and normocalcemia. Our patient had bilateral hand involvement, including local calcinosis cutis of the skin and bone changes not previously reported in the literature. At a 2-year follow-up after two lesions were excised from her left hand, one lesion had completely resolved and the other recurred. Two large symptomat...
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#2Guansheng Tong (Capital Medical University)H-Index: 1
Last. Zhe Wen (Capital Medical University)
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Pulmonary artery involvement can occur in about half of the patients suffering Takayasu arteritis. Increased FDG activity in the aorta and its main branches in patients with Takayasu arteritis on PET/CT had been well-reported. However, the FDG PET/CT appearance of pulmonary artery involvement in Takayasu arteritis is less known. We present FDG PET/CT findings in a 37-year-old patient with known Takayasu arteritis. The images showed rim-like FDG activity in opacities in the left lung, which was l...
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#1Isamu MiuraH-Index: 1
#2Motoo KubotaH-Index: 1
Last. Masahito YuzuriharaH-Index: 4
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Tumoral calcinosis involving the spine is rare. The involvement of the thoracic spine is rarer than that of the cervical or lumbar spine. We report a case of thoracic tumoral calcinosis accompanied by vertebral fracture with increased concentrations of inflammatory markers and no abnormalities in serum calcinosis and phosphorus concentration. A 60-year-old woman presented with complete paraplegia. Her white blood cell count and C-reactive protein (CRP) concentration were elevated. The thoracic m...
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#1Wichana Chamroonrat (MU: Mahidol University)H-Index: 13
#1Wichana Chamroonrat (MU: Mahidol University)H-Index: 2
Fever in children is common. If it persists and its cause cannot be identified in a reasonable time, along with laboratory and conventional imaging investigations, it is defined as fever of unknown origin (FUO). 18F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) is well established in the evaluation of malignancy, which is a possible cause of FUO. FDG often locates inflammatory and infectious lesions considered nonspecific or false-positive for oncology; however, these findings are benefi...
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