Strontium chondroitin sulfate/silk fibroin blend membrane containing microporous structure modulates macrophage responses for guided bone regeneration

A membrane used for guided bone regeneration (GBR) serves as a bioactive compartment rather than a physical barrier. However, the pure membrane may not provide an optimal microenvironment for bone formation and remodeling. Here, a novel strontium chondroitin sulfate/silk fibroin (SrCS/SF) blend membrane containing microporous structure was fabricated. By increasing incorporation content of SrCS, SrCS/SF membranes exhibit better mechanical...