The microRNAs miR-449a and miR-424 suppress osteosarcoma by targeting cyclin A2 expression
Abstract
MicroRNAs of the miR-16 and miR-34 families have been reported to inhibit cell cycle progression, and their loss has been linked to oncogenic transformation. Utilizing a high-throughput, genome-wide screen for miRNAs and mRNAs that are differentially regulated in osteosarcoma (OS) cell lines, we report that miR-449a and miR-424, belonging to the miR-34 and miR-16 families, respectively, target the major S/G2 phase cyclin, cyclin A2 (CCNA2), in a...
Paper Details
Title
The microRNAs miR-449a and miR-424 suppress osteosarcoma by targeting cyclin A2 expression
Published Date
Mar 1, 2019
Volume
294
Issue
12
Pages
4381 - 4400
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