Vasa nervorum angiogenesis in prostate cancer with perineural invasion

Background Perineural invasion (PNI) is generally accepted as a major route of cancer dissemination in malignancies associated with highly enervated organs. However, the effect of cancer cells on vasa nervorum remains unknown. We studied this effect in locally advanced prostate cancer, a high‐risk feature associated with approximately 20% of prostate cancer specific mortality. Methods We used immunohistochemistry for CD34, fibroblast growth...