Correlations between Apparent Diffusion Coefficient and Gleason Score in Prostate Cancer: A Systematic Review.

Published on Aug 1, 2020in European Urology Oncology7.479
· DOI :10.1016/J.EUO.2018.12.006
Alexey Surov28
Estimated H-index: 28
(Leipzig University),
Hans Jonas Meyer20
Estimated H-index: 20
(Leipzig University),
Andreas Wienke31
Estimated H-index: 31
(MLU: Martin Luther University of Halle-Wittenberg)
Sources
Abstract
Abstract Background Reported data regarding the associations between apparent diffusion coefficient (ADC) of diffusion-weighted imaging (DWI) and Gleason score in prostate cancer (PC) are inconsistent. Objective The aim of the present systematic review was to analyze relationships between ADC and Gleason score in PC. Design, setting, and participants MEDLINE library, SCOPUS, and EMBASE databases were screened for relationships between ADC and Gleason score in PC up to April 2018. Overall, 39 studies with 2457 patients were identified. Data on the following parameters were extracted from the literature: number of patients, cancer localization, and correlation coefficients between ADC and Gleason score. Outcome measurements and statistical analysis Associations between ADC and Gleason score were analyzed by the Spearman's correlation coefficient. Results and limitations In overall sample, the pooled correlation coefficient between ADC and Gleason score was −0.45 (95% confidence interval [CI]=[−0.50; −0.40]). In PC in the transitional zone, the pooled correlation coefficient was −0.22 (95% CI=[−0.47; 0.03]). In PC in the peripheral zone, the pooled correlation coefficient was −0.48 (95% CI=[−0.54; −0.42]). Conclusions In PC located in the peripheral zone, ADC correlated moderately with Gleason score. In PC located in the translational zone, ADC correlated weakly with Gleason score. Patient summary We reviewed studies using apparent diffusion coefficient for the prediction of Gleason score in prostate cancer patients.
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References68
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#1Teng Ma (SDU: Shandong University)H-Index: 1
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#1Alexey Surov (Leipzig University)H-Index: 28
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// Alexey Surov 1, * , Hans Jonas Meyer 1, * and Andreas Wienke 2, * 1 Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany 2 Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany * All authors contributed equally for this work Correspondence to: Alexey Surov, email: Alexey.Surov@medizin.uni-leipzig.de Keywords: DWI, MRI, ADC, cellularity, tumor Received: March 31, 2017 Accept...
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BackgroundFew studies have focused on comparing the utility of diffusion-weighted imaging (DWI) and transrectal ultrasound (TRUS)-guided biopsy in predicting prostate cancer aggressiveness. Whether apparent diffusion coefficient (ADC) values can provide more information than TRUS-guided biopsy should be confirmed.PurposeTo retrospectively assess the utility of ADC values in predicting prostate cancer aggressiveness, compared to the TRUS-guided prostate biopsy Gleason score (GS).Material and Meth...
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