Internal medicine

Tumor microenvironment

Melanoma

Immunotherapy

Tumor-infiltrating lymphocytes

Cancer

Immunohistochemistry

Stromal cell

Immunology

Pancreatic tumor

CD68

Pancreatic cancer

Immune checkpoint

Cancer research

Medicine

Immune system

Proceedings of the National Academy of Sciences

Significance The study demonstrates that V-domain immunoglobulin suppressor of T cell activation (VISTA) is an immune checkpoint that is preferentially expressed at higher levels in pancreatic cancer. The study gives a detailed analysis of immune infiltration in primary and metastatic pancreatic tumors compared with melanoma, which differs in its tumor/stromal distribution. Our data indicate that human pancreatic tumors express CD68 + macrophages and highlight the inhibitory checkpoint molecule VISTA as a potential immunotherapeutic target in pancreatic cancer.

Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer