N-degron and C-degron pathways of protein degradation

Volume: 116, Issue: 2, Pages: 358 - 366
Published: Jan 7, 2019
Abstract
This perspective is partly review and partly proposal. N-degrons and C-degrons are degradation signals whose main determinants are, respectively, the N-terminal and C-terminal residues of cellular proteins. N-degrons and C-degrons include, to varying extents, adjoining sequence motifs, and also internal lysine residues that function as polyubiquitylation sites. Discovered in 1986, N-degrons were the first degradation signals in short-lived...
Paper Details
Title
N-degron and C-degron pathways of protein degradation
Published Date
Jan 7, 2019
Volume
116
Issue
2
Pages
358 - 366
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