Assessing the impact of inadequate hydration on isotope-GFR measurement

Published on Jan 7, 2019in Scandinavian Journal of Clinical & Laboratory Investigation1.475
· DOI :10.1080/00365513.2018.1555859
Tania Telford1
Estimated H-index: 1
(Leeds Teaching Hospitals NHS Trust),
David F. Keane7
Estimated H-index: 7
(Leeds Teaching Hospitals NHS Trust)
+ 3 AuthorsMark C. Barnfield7
Estimated H-index: 7
(Leeds Teaching Hospitals NHS Trust)
AbstractGuidelines state that patients undergoing isotope glomerular filtration rate (GFR) tests should maintain adequate hydration, but pragmatically these tests can coincide with procedures requiring the patient not to eat or drink (‘nil-by-mouth’) for up to 12 hours beforehand. This study investigated the impact of a 12-hour nil-by-mouth regime on GFR measurement. Twelve healthy volunteers were recruited from our institution. Exclusion criteria included diabetes mellitus, being under 18 years of age and pregnancy. Isotope GFR measurements were carried out on these volunteers twice. One of the tests adhered strictly to the British Nuclear Medicine Society (BNMS) guidelines for GFR measurement and the other test was carried out after the volunteers had refrained from eating or drinking anything for 12 hours. The order of these tests was randomly assigned. The results show that after a nil-by-mouth regime, participants’ average absolute GFR fell from 108 ml/min to 97 ml/min (p < .01), while normalised GFR...
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