Original paper
Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury
Abstract
The clearance of damaged myelin sheaths is critical to ensure functional recovery from neural injury. Here we show a previously unidentified role for microvessels and their lining endothelial cells in engulfing myelin debris in spinal cord injury (SCI) and experimental autoimmune encephalomyelitis (EAE). We demonstrate that IgG opsonization of myelin debris is required for its effective engulfment by endothelial cells and that the...
Paper Details
Title
Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury
Published Date
Jan 21, 2019
Journal
Volume
22
Issue
3
Pages
421 - 435
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Notes
History