Erastin decreases radioresistance of NSCLC cells partially by inducing GPX4‑mediated ferroptosis

The aim of the present study was to examine whether erastin influences radioresistance in non‑small cell lung cancer (NSCLC) cells and produce a preliminary investigation into its mechanism of action. The radioresistant subtype of NSCLC cells, A549‑R and H460‑R, were induced by high‑dose hypofractionated irradiation. Erastin was used to treat the radioresistant cells and radiosensitivity was examined by colony formation assays. Cell death was...