Receptor

Bacterial adhesin

Bacteria

Biology

Microbiology

Gene

Pilus

Pathogen

Colonization

Pseudomonas aeruginosa

Cell biology

Genetics

Virulence

Cell Host & Microbe

Laventie et al. demonstrate that upon host cell contact, Pseudomonas aeruginosa rapidly activates a c-di-GMP-dependent surface program to promote adherence and virulence. Polar localization of c-di-GMP-interacting proteins triggers pili activation. Asymmetric divisions on surfaces produce specialized cell types, a spreader for dissemination and a striker for local tissue damage.

A Surface-Induced Asymmetric Program Promotes Tissue Colonization by Pseudomonas aeruginosa