Is there a genetic basis to the different morphological subtypes of bicuspid aortic valve

Published on Dec 24, 2018in Annals of Translational Medicine3.297
· DOI :10.21037/ATM.2018.12.21
Talha Niaz8
Estimated H-index: 8
(Mayo Clinic),
Donald J. Hagler88
Estimated H-index: 88
(Mayo Clinic)
Sources
Abstract
Bicuspid aortic valve (BAV) is one of the most common congenital heart defects leading to a significant global financial health burden as a result of its complications (1). BAV can lead to premature aortic valve disease in the form of aortic valve stenosis or regurgitation requiring multitude of interventions on aortic valve, including transcatheter interventions or surgical valve replacement. BAV disease is a continuum of disease process that not only affects the aortic valve but also extends to the thoracic aorta leading to dilatation with risk of aortic aneurysm and dissection. Even though the impacts of BAV are far and wide spread and despite decades of research and investigation, we still lack a clear understanding of the genetic and molecular pathophysiology of BAV (2).
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Cited By3
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#1Grzegorz Lis (Jagiellonian University Medical College)H-Index: 15
#2Andrzej Dubrowski (Jagiellonian University Medical College)H-Index: 1
Last. Jan A. Litwin (Jagiellonian University Medical College)H-Index: 11
view all 10 authors...
Aortic valve interstitial cells (VICs) constitute a heterogeneous population involved in the maintenance of unique valvular architecture, ensuring proper hemodynamic function but also engaged in valve degeneration. Recently, cells similar to telocytes/interstitial Cajal-like cells described in various organs were found in heart valves. The aim of this study was to examine the density, distribution, and spatial organization of a VIC subset co-expressing CD34 and PDGFRα in normal aortic valves and...
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#1Calogera PisanoH-Index: 11
#2Federico D’AmicoH-Index: 4
Last. Augusto OrlandiH-Index: 54
view all 14 authors...
Background We sought to investigate and compare biomechanical properties and histomorphometric findings of thoracic ascending aorta aneurysm (TAA) tissue from patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) in order to clarify mechanisms underlying differences in the clinical course. Methods Circumferential sections of TAA tissue in patients with BAV (BAV-TAA) and TAV (TAV-TAA) were obtained during surgery and used for biomechanical tests and histomorphometrical analys...
1 CitationsSource
#1Borja Fernández (UMA: University of Málaga)H-Index: 19
#2María Teresa Soto-Navarrete (UMA: University of Málaga)H-Index: 3
Last. M. Carmen Fernández (UMA: University of Málaga)H-Index: 18
view all 6 authors...
Bicuspid aortic valve (BAV) is the most common human congenital cardiac malformation. Although the etiology is unknown for most patients, formation of the 2 main BAV anatomic types (A and B) has be...
2 CitationsSource