Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics

Volume: 16, Issue: 12, Pages: e2006265 - e2006265
Published: Dec 20, 2018
Abstract
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease with the microtubule-binding protein tau, but the mechanism of action of LRRK2 mutations and the molecular connection between tau and Parkinson disease are unclear. Here, we investigate the interaction of LRRK and tau in Drosophila and mouse models of tauopathy. We find that either...
Paper Details
Title
Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics
Published Date
Dec 20, 2018
Volume
16
Issue
12
Pages
e2006265 - e2006265
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