aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability

Volume: 9, Issue: 1
Published: Dec 17, 2018
Abstract
Strict regulation of proliferation is vital for development, whereas unregulated cell proliferation is a fundamental characteristic of cancer. The polarity protein atypical protein kinase C lambda/iota (aPKCλ) is associated with cell proliferation through unknown mechanisms. In endothelial cells, suppression of aPKCλ impairs proliferation despite hyperactivated mitogenic signaling. Here we show that aPKCλ phosphorylates the DNA binding domain of...
Paper Details
Title
aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability
Published Date
Dec 17, 2018
Volume
9
Issue
1
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