Original paper
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
Abstract
The mammalian liver possesses a remarkable regenerative ability. Two modes of damage response have been described: (1) The "oval cell" response emanates from the biliary tree when all hepatocytes are affected by chronic liver disease. (2) A massive, proliferative response of mature hepatocytes occurs upon acute liver damage such as partial hepatectomy (PHx). While the oval cell response has been captured in vitro by growing organoids from...
Paper Details
Title
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
Published Date
Nov 1, 2018
Journal
Volume
175
Issue
6
Pages
1591 - 1606.e19
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Notes
History