Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect

Published on Jan 21, 2021in Biomedical Materials3.174
· DOI :10.1088/1748-605X/ABDE6F
Amela Trbakovic3
Estimated H-index: 3
,
Amela Trbakovic (Uppsala University Hospital)+ 6 AuthorsPatricia Hedenqvist7
Estimated H-index: 7
Source
Abstract
Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect
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The repair of large cranial defects with bone is a major clinical challenge that necessitates novel materials and engineering solutions. Three-dimensionally (3D) printed bioceramic (BioCer) implants consisting of additively manufactured titanium frames enveloped with CaP BioCer or titanium control implants with similar designs were implanted in the ovine skull and at s.c. sites and retrieved after 12 and 3 mo, respectively. Samples were collected for morphological, ultrastructural, and compositi...
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Abstract Reconstructing large bone defects caused by severe trauma or resection of tumors remains a challenge for surgeons. A fibula free flap and its vascularized bed can be transplanted to the reconstruction site to achieve healing. However, this technique adds morbidity, requires microsurgery and sculpting of the bone tissue to adapt the graft to both the vasculature and the anatomy of the defect respectively. The aim of the current study is to evaluate an alternative approach consisting of t...
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In animal studies on bone healing, the effect of housing space and physical activity are seldom taken into account. Bone formation was evaluated in New Zealand White rabbits (mean ± SEM BW: 3.9 ± 0.11 kg) with a critical bone defect after 12 weeks of rehabilitation in pair-housing in 3 m2 large floor pens (Floor, n = 10) or standard single housing in 0.43 m2 cages (Cage, n = 10). In the randomised full-factorial study, a bone replica of calcium phosphate cement (CPC, n = 10) or autologous bone (...
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Although autografts are considered to be the gold standard treatment for reconstruction of large bone defects resulting from trauma or diseases, donor site morbidity and limited availability restrict their use. Successful bone repair also depends on sufficient vascularization and to address this challenge, novel strategies focus on the development of vascularized biomaterial scaffolds. This pilot study aimed to investigate the feasibility of regenerating large bone defects in sheep using 3D-prin...
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