Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect

Published on Jan 21, 2021in Biomedical Materials3.174
· DOI :10.1088/1748-605X/ABDE6F
Amela Trbakovic3
Estimated H-index: 3
 , Amela Trbakovic (Uppsala University Hospital)+ 6 AuthorsPatricia Hedenqvist7
Estimated H-index: 7
Source
Abstract
Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect
📖 Papers frequently viewed together
199610.32Biomaterials
4 Authors (A. Piattelli, ..., S. Matarasso)
66 Citations
20173.87Stem Cells International
7 Authors (Peer W. Kämmerer, ..., Hermann Lang)
15 Citations
20133.74Journal of Periodontology
7 Authors (Cristiane Ibanhes Polo, ..., Wilson Roberto Sendyk)
20 Citations
References47
Newest
Oct 27, 2020·Proceedings of the National Academy of Sciences of the United States of America9.41
#1Omar Omar (University of Gothenburg)H-Index: 23
#2Thomas Engstrand (Karolinska University Hospital)H-Index: 16
Last. Peter Thomsen (University of Gothenburg)H-Index: 55
view all 11 authors...
The repair of large cranial defects with bone is a major clinical challenge that necessitates novel materials and engineering solutions. Three-dimensionally (3D) printed bioceramic (BioCer) implants consisting of additively manufactured titanium frames enveloped with CaP BioCer or titanium control implants with similar designs were implanted in the ovine skull and at s.c. sites and retrieved after 12 and 3 mo, respectively. Samples were collected for morphological, ultrastructural, and compositi...
3 CitationsSource
Jul 18, 2020·Acta Biomaterialia7.24
#1Luciano Vidal (University of Nantes)H-Index: 3
#2Meadhbh Á. Brennan (University of Nantes)H-Index: 17
Last. Pierre Layrolle (University of Nantes)H-Index: 59
view all 8 authors...
Abstract Reconstructing large bone defects caused by severe trauma or resection of tumors remains a challenge for surgeons. A fibula free flap and its vascularized bed can be transplanted to the reconstruction site to achieve healing. However, this technique adds morbidity, requires microsurgery and sculpting of the bone tissue to adapt the graft to both the vasculature and the anatomy of the defect respectively. The aim of the current study is to evaluate an alternative approach consisting of t...
2 CitationsSource
May 21, 2020·PLOS ONE2.74
#1Patricia Hedenqvist (SLU: Swedish University of Agricultural Sciences)H-Index: 7
#2Amela Trbakovic (Uppsala University)H-Index: 3
Last. Andreas Thor (Uppsala University)H-Index: 15
view all 10 authors...
In animal studies on bone healing, the effect of housing space and physical activity are seldom taken into account. Bone formation was evaluated in New Zealand White rabbits (mean ± SEM BW: 3.9 ± 0.11 kg) with a critical bone defect after 12 weeks of rehabilitation in pair-housing in 3 m2 large floor pens (Floor, n = 10) or standard single housing in 0.43 m2 cages (Cage, n = 10). In the randomised full-factorial study, a bone replica of calcium phosphate cement (CPC, n = 10) or autologous bone (...
1 CitationsSource
Apr 27, 2020·Scientific Reports4.00
#1Luciano Vidal (University of Nantes)H-Index: 3
#2Carina Kampleitner (University of Vienna)H-Index: 3
Last. Pierre Layrolle (University of Nantes)H-Index: 59
view all 10 authors...
Although autografts are considered to be the gold standard treatment for reconstruction of large bone defects resulting from trauma or diseases, donor site morbidity and limited availability restrict their use. Successful bone repair also depends on sufficient vascularization and to address this challenge, novel strategies focus on the development of vascularized biomaterial scaffolds. This pilot study aimed to investigate the feasibility of regenerating large bone defects in sheep using 3D-prin...
5 CitationsSource
Feb 12, 2020·Frontiers in Bioengineering and Biotechnology3.64
#1Luciano Vidal (University of Nantes)H-Index: 3
#2Carina Kampleitner (University of Vienna)H-Index: 3
Last. Pierre Layrolle (University of Nantes)H-Index: 59
view all 5 authors...
The healing of bone fractures is a well-orchestrated physiological process involving multiple cell types and signaling molecules interacting at the fracture site to replace and repair bone tissue without scar formation. However, when the lesion is too large, normal healing is compromised. These so-called non-union bone fractures, mostly arising due to trauma, tumor resection or disease, represent a major therapeutic challenge for orthopedic and reconstructive surgeons. In this review, we firstly...
17 CitationsSource
Feb 1, 2019·World Neurosurgery1.83
#1Lars Kihlström Burenstam Linder (Karolinska University Hospital)H-Index: 2
#2Ulrik Birgersson (KI: Karolinska Institutet)H-Index: 7
Last. Thomas Engstrand (Uppsala University)H-Index: 16
view all 5 authors...
Background The reconstruction of complex cranial defects is challenging and is associated with a high complication rate. The development of a patient-specific, titanium-reinforced, calcium phosphate–based (CaP-Ti) implant with bone regenerative properties has previously been described in 2 case studies with the hypothesis that the implant may improve clinical outcome. Objective To identify whether the introduction of CaP-Ti implant has the potential to improve clinical outcome. Methods A retrosp...
15 CitationsSource
Nov 1, 2018·Injury-international Journal of The Care of The Injured2.11
#1David Wennergren (University of Gothenburg)H-Index: 7
#2Carl Bergdahl (University of Gothenburg)H-Index: 2
Last. Michael Möller (University of Gothenburg)H-Index: 14
view all 6 authors...
Abstract Introduction There is a lack of epidemiological studies of fractures in all segments of the tibia classified by orthopaedic surgeons according to the AO/OTA classification. Since 2011, the Swedish Fracture Register (SFR) has provided prospectively collected, population-based data on fractures of all types, treated both surgically and non-surgically. The aim of this study was to describe the epidemiology and incidence of fractures in all segments of the tibia in a cohort of consecutive t...
22 CitationsSource
Oct 1, 2018·Acta Biomaterialia7.24
#1Albert Barba (UPC: Polytechnic University of Catalonia)H-Index: 4
#2Yassine Maazouz (UPC: Polytechnic University of Catalonia)H-Index: 8
Last. Maria-Pau Ginebra (UPC: Polytechnic University of Catalonia)H-Index: 49
view all 12 authors...
Abstract There is an urgent need of synthetic bone grafts with enhanced osteogenic capacity. This can be achieved by combining biomaterials with exogenous growth factors, which however can have numerous undesired side effects, but also by tuning the intrinsic biomaterial properties. In a previous study, we showed the synergistic effect of nanostructure and pore architecture of biomimetic calcium deficient hydroxyapatite (CDHA) scaffolds in enhancing osteoinduction, i.e. fostering the differentia...
29 CitationsSource
Dec 16, 2017·Journal of Dentistry3.24
#1Amela Trbakovic (Uppsala University)H-Index: 3
#2Patricia Hedenqvist (SLU: Swedish University of Agricultural Sciences)H-Index: 7
Last. Andreas Thor (Uppsala University)H-Index: 15
view all 10 authors...
Abstract Objectives The aim of this study was to investigate if a synthetic granular calcium phosphate compound (CPC) and a composite bisphosphonate-linked hyaluronic acid–calcium phosphate hydrogel (HABP·CaP) induced similar or more amount of bone as bovine mineral in a modified sinus lift rabbit model. Material and methods Eighteen adult male New Zeeland White rabbits, received randomly one of the two test materials on a random side of the face, and bovine mineral as control on the contralater...
8 CitationsSource
Oct 1, 2017·Journal of The Mechanical Behavior of Biomedical Materials3.37
#1Ingrid Ajaxon (Uppsala University)H-Index: 7
#2Alice AcciaioliH-Index: 1
Last. Cecilia Persson (Uppsala University)H-Index: 20
view all 7 authors...
Calcium phosphate cements (CPCs) should ideally have mechanical properties similar to those of the bone tissue the material is used to replace or repair. Usually, the compressive strength of the CPCs is reported and, more rarely, the elastic modulus. Conversely, scarce or no data are available on Poisson's ratio and strain-to-crack-initiation. This is unfortunate, as data on the elastic response is key to, e.g., numerical model accuracy. In this study, the compressive behaviour of brushite, mone...
20 CitationsSource
12345
Cited By0
Newest