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doi.org/10.1016/j.stemcr.2018.10.008

Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium

..., Thomas Eschenhagen
76
Stem Cell Reports5.90
Volume: 11, Issue: 6, Pages: 1378 - 1390
Published: Dec 1, 2018
Abstract
Cardiomyocytes (CMs) generated from human induced pluripotent stem cells (hiPSCs) are under investigation for their suitability as human models in preclinical drug development. Antiarrhythmic drug development focuses on atrial biology for the treatment of atrial fibrillation. Here we used recent retinoic acid-based protocols to generate atrial CMs from hiPSCs and establish right atrial engineered heart tissue (RA-EHT) as a 3D model of human...
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Paper Details
Title
Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium
DOI
doi.org/10.1016/j.stemcr.2018.10.008
Published Date
Dec 1, 2018
Journal
Stem Cell Reports
Volume
11
Issue
6
Pages
1378 - 1390
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