Design and Preclinical Evaluation of an Albumin-Binding PSMA Ligand for ⁶⁴Cu-Based PET Imaging

Recently, we developed an albumin-binding radioligand (177Lu–PSMA–ALB-56), which showed higher PSMA-specific tumor uptake in mice than the previously developed 177Lu–PSMA-617 under the same experimental conditions. Such a radioligand may be of interest also for PET imaging, possibly enabling better visualization of even small metastases at late time-points after injection. The aim of this study was, therefore, to modify PSMA–ALB-56 by exchanging...