Effects of icariin on ovarian function in d-galactose-induced aging mice

Published on Feb 1, 2019in Theriogenology2.094
· DOI :10.1016/J.THERIOGENOLOGY.2018.10.028
Jun-Li Wang2
Estimated H-index: 2
(H.I., S.I.: University of Agriculture, Faisalabad),
Bing Liu2
Estimated H-index: 2
(H.I., S.I.: University of Agriculture, Faisalabad)
+ 5 AuthorsJian-Ming Gao3
Estimated H-index: 3
(H.I., S.I.: University of Agriculture, Faisalabad)
Abstract In this study, effects of icariin (Ica) on were examined in a mouse model of d -galactose (D-gal)-induced ovarian aging. Kunming white mice were divided into three groups: aging group induced with D-gal, experiment group treated with Ica at low (50 mg/kg), middle (100 mg/kg) and high (200 mg/kg) concentrations, and control group with no treatment. Ovarian histomorphology, serum FSH, LH and E2 levels, and reproductive function were compared among the groups. Ovarian expression of Amh, Bax and Bcl-2 was examined by qPCR and western blotting. Our results showed that diameters of secondary and tertiary follicles were significantly reduced in the aging group when compared with control group (P
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