Original paper
eIF2B activator prevents neurological defects caused by a chronic integrated stress response
Abstract
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2B. Vanishing White Matter (VWM) is a neurological disease caused by eIF2B mutations that, like phosphorylated eIF2, reduce its activity. We show that introduction of a human VWM mutation into mice...
Paper Details
Title
eIF2B activator prevents neurological defects caused by a chronic integrated stress response
Published Date
Jan 9, 2019
Journal
Volume
8