A Sparse Orthogonal Collimator for Small Animal IMRT Using Rectangular Aperture Optimization

Small animal studies are crucial for evaluating the safety and efficacy of new radiotherapy strategies, but their translatability to clinical outcomes is limited by the crude irradiation techniques typically used. Although image guided small animal irradiators have been recently developed, they still lack the intensity modulation capability that is an integral part of human treatment. Multileaf collimators (MLC) and fluence map inverse...