Epidemiology of Adults and Children Treated for Nontuberculous Mycobacterial Pulmonary Disease in Japan.

Published on Oct 19, 2018in Annals of the American Thoracic Society6.831
· DOI :10.1513/ANNALSATS.201806-366OC
Kiyohiko Izumi7
Estimated H-index: 7
,
Kozo Morimoto15
Estimated H-index: 15
+ 4 AuthorsSatoshi Mitarai15
Estimated H-index: 15
(Nagasaki University)
Sources
Abstract
Rationale: The epidemiology of nontuberculous mycobacterial pulmonary disease (NTM-PD) remains unclear in the majority of countries, including Japan.Objectives: To estimate the nationwide incidence...
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References15
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#1Kozo MorimotoH-Index: 15
#2Akio AonoH-Index: 14
Last. Satoshi MitaraiH-Index: 24
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Reinfection of nontuberculous mycobacterium pulmonary disease may be caused by identical and not different genotypes http://ow.ly/62cH30krdpa
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#1Hiroaki NaganoH-Index: 74
#2Takeshi Kinjo (University of the Ryukyus)H-Index: 18
Last. Tomoo KishabaH-Index: 10
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Nontuberculous mycobacteria (NTM) lung disease is increasing globally. Although the etiological epidemiology of NTM is different across regions, Mycobacterium avium complex (MAC) is the leading cause of NTM lung disease in most countries, including mainland Japan. Okinawa is located in the southernmost region of Japan and is the only prefecture categorized as a subtropical region in Japan, it is therefore likely the etiological epidemiology of NTM lung disease is different from mainland Japan. F...
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#1Roland DielH-Index: 60
#2Josephine Jacob (Elsevier)H-Index: 7
Last. Felix C. Ringshausen (MHH: Hannover Medical School)H-Index: 25
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The objective of this study was to estimate the burden of disease in incident patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD). A sample of 7 073 357 anonymised persons covered by German public statutory health insurances was used to identify patients with NTM-PD. In total, 125 patients with newly diagnosed NTM-PD in 2010 and 2011 were matched with 1250 control patients by age, sex and Charlson Comorbidity Index, and followed for 39 months. The incidence rate for NTM-PD was...
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#1Man Wah YeungH-Index: 3
#2Edwin KhooH-Index: 6
Last. Beate SanderH-Index: 23
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Nontuberculous mycobacterial (NTM) infections are increasing in disease frequency worldwide. This systematic review examines health-related quality of life (HRQOL), comorbidities and mortality associated with pulmonary NTM disease. We searched MEDLINE, EMBASE, CINAHL, Scopus Life Sciences, conference proceedings and Google (earliest date available to February 2015) for primary studies. Eligible studies compared populations with and without pulmonary NTM disease in high-income jurisdictions. We e...
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#1Ho NamkoongH-Index: 20
#2Atsuyuki KurashimaH-Index: 19
Last. Satoshi Mitarai (Nagasaki University)H-Index: 15
view all 7 authors...
Rationale: In recent years, the number of pulmonary nontuberculous mycobacterial (PNTM) disease has been expected to be increasing in Japan. The latest epidemiological survey conducted in 2007 using the previous criteria showed that the incidence of PNTM was calculated to be 5.7 cases per 100,000 person-years by comparing the ratio of PNTM and pulmonary tuberculosis (PTB) patients. Therefore, the precise updated data has been urgently required. Methods: In 2014, questionnaires were sent to 884 J...
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#1Mina Gochi (Saitama Prefecture)H-Index: 1
#2Noboru TakayanagiH-Index: 21
Last. Yutaka SugitaH-Index: 19
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Objectives Some patients with nodular/bronchiectatic Mycobacterium avium complex lung disease (NB MAC-LD) deteriorate and die. The main aim of the study is to evaluate the prognostic factors and radiographic outcomes in patients with NB MAC-LD. Setting Retrospective single-centre review. Participants 782 HIV-negative patients with NB MAC-LD treated at our institution in Japan. Primary and secondary outcome measures All-cause and MAC-LD progression mortality rates and the prognostic factors, and ...
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#1D. Rebecca Prevots (NIH: National Institutes of Health)H-Index: 34
#2Theodore K. Marras (Toronto Western Hospital)H-Index: 11
Population-based data have documented a continued increase in NTM prevalence since 2000. Annual prevalence in North American and Australia ranges from 3.2–9.8 per 100,000, and is generally higher than in Europe. Studies of NTM PD from South Korea, Japan, and Taiwan, also suggest increasing prevalence. In Africa and the Middle East, prevalence of NTM ranges from 4% –15% among suspected TB cases and 18%–20% among suspected multi-drug resistant TB (MDR TB) cases. M. avium complex (MAC) is predomina...
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#1Kozo MorimotoH-Index: 15
#2Kazuro IwaiH-Index: 4
Last. Shoji KudohH-Index: 65
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Rationale: Pulmonary disease caused by nontuberculous mycobacteria is generally reported to have a good prognosis. However, the actual mortality rate over time has not been reported in a large-scale survey.Objectives: To determine the annual trend in mortality from nontuberculous mycobacteriosis, based on nearly four decades of patient data, and to estimate the prevalence of these cases in 2005.Methods: The annual mortality rate and regional distribution of nontuberculous mycobacteriosis–related...
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#1Shinya Matsuda (University of Occupational and Environmental Health Japan)H-Index: 34
#2Kenji Fujimori (Hokkaido University)H-Index: 20
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Rationale: The prognostic factors of Mycobacterium avium complex lung disease (MAC-LD) are not clearly defined.Objectives: To assess the prognostic factors of all-cause and MAC-specific mortality in patients with MAC-LD, especially in accordance with radiographic features, first-line treatment, and host predisposition.Methods: Medical records of 634 HIV-negative patients with MAC-LD treated at our institution in Saitama, Japan were retrospectively analyzed.Measurements and Main Results: Patients...
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#1Jakko van Ingen (Radboud University Nijmegen)H-Index: 50
Last. Charles L. Daley (University of Colorado Denver)H-Index: 71
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Introduction null Nontuberculous mycobacterial (NTM) lung disease (LD) is the most common clinical manifestation of NTM infection and is a growing health concern. Up to 85% of NTM-LD cases are caused by Mycobacterium avium complex (MAC). Increased awareness of NTM-LD caused by MAC is needed as patients with this disease experience substantial burden and unmet treatment needs. null Areas covered null This review provides clinicians and regulatory and healthcare decision makers an overview of the ...
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#1Hiromu Morikubo (Kyorin University)H-Index: 2
#2Taku Kobayashi (Kitasato University)H-Index: 30
Last. Toshifumi Hibi (Kitasato University)H-Index: 98
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Background Real-world big data studies using health insurance claims databases require extraction algorithms to accurately identify target population and outcome. However, no algorithm for Crohn’s disease (CD) has yet been validated. In this study we aim to develop an algorithm for identifying CD using the claims data of the insurance system. null null Methods A single-center retrospective study to develop a CD extraction algorithm from insurance claims data was conducted. Patients visiting the ...
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#1Kozo MorimotoH-Index: 15
#2Manabu AtoH-Index: 28
Last. Satoshi MitaraiH-Index: 24
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This study aimed to clarify the population-based distributions of Mycobacterium avium and Mycobacterium intracellulare in Japan. We conducted a combined analysis of the national insurance claim and microbiological databases. The incidence rates of M. avium by province were similar throughout the country, with some exceptions, such as in Okinawa, probably because the bathing customs are different from those in mainland Japan. In contrast, M. intracellulare showed a gradual increase from the centr...
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#1Takahiro Ando (UTokyo: University of Tokyo)H-Index: 7
#2Hidenori Kage (UTokyo: University of Tokyo)H-Index: 14
Last. Takahide Nagase (UTokyo: University of Tokyo)H-Index: 44
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Abstract null null Background null Ethambutol ocular toxicity is a major problem during combination chemotherapy for Mycobacterium avium complex (MAC) pulmonary disease (MAC-PD) due to years-long therapy for MAC. null null null Objectives null This study aimed to identify the lower dose of daily ethambutol that can reduce ocular toxicity. null null null Methods null We retrospectively reviewed the medical records of 312 patients who visited The University of Tokyo Hospital between January 2007 a...
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#1Goh Tanaka (UTokyo: University of Tokyo)H-Index: 10
#2Taisuke Jo (UTokyo: University of Tokyo)H-Index: 17
Last. Takahide Nagase (UTokyo: University of Tokyo)H-Index: 44
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The incidence and prevalence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) are reportedly increasing in many parts of the world. However, there are few published data on NTM-PD-related death. Using data from a national inpatient database in Japan, we aimed in this study to identify the characteristics of patients with NTM-PD and clinical deterioration and to identify risk factors for in-hospital mortality. We examined data from the Diagnosis Procedure Combination (DPC) database in ...
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#1Ko Harada (Okayama University)H-Index: 6
#2Hideharu Hagiya (Okayama University)H-Index: 13
Last. Fumio Otsuka (Okayama University)H-Index: 36
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BACKGROUND The incidence of nontuberculous mycobacterial (NTM) infections has been increasing worldwide, becoming a significant healthcare burden especially among elderly people. This study aimed to evaluate the trends in NTM-associated mortality in Japan. METHODS This study used vital statistics data and data on all NTM-associated deaths (N=18,814) among individuals aged ≥40 years in Japan from 1997 to 2016. We calculated the crude and age-adjusted mortality rates by age and sex and used joinpo...
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#1David E. GriffithH-Index: 61
#2Theodore K. Marras (UHN: University Health Network)H-Index: 23
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#1Norio Kodaka (Toho University)H-Index: 2
#2Chihiro Nakano (Toho University)H-Index: 4
Last. Hiroto Matsuse (Toho University)H-Index: 24
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Abstract null null Objectives: Mycobacterium avium complex pulmonary disease (MAC-PD) can be serologically diagnosed according to the presence of anti-glycopeptidolipid (GPL)-core IgA antibodies. However, few studies have examined the association between serum anti-GPL-core IgA antibody titers and the clinical characteristics of patients with MAC-PD. null Methods: From April 2014 to June 2019, we determined the level of anti-GPL-core IgA antibodies in 489 MAC-PD patients at our institute. Of the...
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ABSTRACT The experience and causes of pain in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) have not been clarified.This study aimed to determine the prevalence and severity of bodily pain (BP) in patients with NTM-PD. We also investigated the clinical indicators that contribute to pain.We used a retrospective cross-sectional study design. The participants were 114 NTM-PD patients (109 women) with a mean age of 65 years. The prevalence and severity of pain were measured u...
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Non-tuberculous mycobacterial pulmonary disease is on the rise globally. It is often missed, and causes significant morbidity and even mortality. Here, members of a clinical research network and a patient support group discuss some of the current key issues in NTM management. In addition to the need for research into epidemiology, immunology and treatment, we recommend greater use of patient and clinician networks to: (i) educate primary and secondary care clinicians to develop a high index of s...
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